DUSP3

Across TCGA patient cohorts, DUSP3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP3-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and Annexin-1. Each is linked with DUSP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP3-to-partner and partner-to-DUSP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DUSP3-low versus DUSP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP3→partner) and Y-score (partner→DUSP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.200	+2.820	.042	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.176	-2.584	.002	.011	3	1
UCEC	Annexin-1 →	+0.685	+2.189	.005	.034	3	1
UCEC	Stathmin →	+0.159	+2.584	.013	.011	3	1
UCEC	ATM →	-0.505	-2.986	.017	.035	3	1
UCEC	Bax →	+0.235	+2.999	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by DUSP3 expression — UCEC

Explore this box plot interactively →