DUSP3

Across TCGA pan-cancer cohorts, DUSP3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DUSP3 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DUSP3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DUSP3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, MESO, and HNSC are the cancer types where DUSP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.716	0.541	<.001	88	view →
MESO	DFS	Median	II,III,IV	0.234	0.667	.001	80	view →
HNSC	OS	Tertile	All	0.308	0.499	<.001	56	view →
BLCA	DFS	Tertile	All	0.285	0.544	.007	40	view →
CESC	DFS	Tertile	All	0.779	0.894	.002	40	view →
LGG	OS	Median	All	0.735	0.884	<.001	37	view →
BRCA	OS	Median	III,IV	0.889	0.765	.005	35	view →
LUAD	OS	Median	IV	0.520	0.837	.006	35	view →
SARC	OS	Median	All	0.625	0.402	<.001	29	view →
KICH	OS	Quartile	All	0.590	1.000	.010	22	view →
UVM	DFS	Tertile	III,IV	0.508	0.929	.008	19	view →
STAD	OS	Tertile	II,III,IV	0.616	0.821	.025	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DUSP3–KIRC (OS)

Open the KIRC breakdown →