DUSP3

Across TCGA cell cohorts, DUSP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,570 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DUSP3-associated GO terms across cancer lineages are Sphingolipid catabolic process, Proteoglycan catabolic process, and Protein targeting to vacuole involved in autophagy. Each is linked with DUSP3 in more than 10 cancer types. Because this analysis shows association rather than direction, both DUSP3-to-partner and partner-to-DUSP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sphingolipid catabolic process grouped by DUSP3-low versus DUSP3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP3→partner) and Y-score (partner→DUSP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Sphingolipid catabolic process →	+0.164	+1.063	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Proteoglycan catabolic process →	+0.179	+0.784	<.001	.004	3	11
STOMACH	Protein targeting to vacuole involved in autophagy →	+0.273	+1.305	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Autophagosome organization →	+0.052	+0.669	.005	.002	3	10
LUNG_SCLC	Negative regulation of cell killing →	+0.153	+0.899	.009	.002	2	11
BLOOD_Myeloma	Autophagosome assembly →	+0.065	+1.905	.009	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,570 associations by consensus.

Sphingolipid catabolic process by DUSP3 expression — BONE

Explore this box plot interactively →