DUSP23

Across TCGA patient cohorts, DUSP23 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible DUSP23-associated genes across cancer lineages are EEF1E1-BLOC1S5, RNA5SP124, and RNU6-1082P. Each is linked with DUSP23 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP23-to-partner and partner-to-DUSP23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by DUSP23-low versus DUSP23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP23→partner) and Y-score (partner→DUSP23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EEF1E1-BLOC1S5 →	+0.050	+4.132	<.001	.009	3	1
UCEC	RNA5SP124 →	+0.715	+3.903	<.001	<.001	3	1
UCEC	RNU6-1082P →	+0.457	+4.136	<.001	.001	3	1
UCEC	TRAJ46 →	+0.447	+4.132	<.001	.009	3	1
UCEC	SNORD90 →	+0.559	+3.670	<.001	.002	3	1
LUSC	RNU6-1059P →	+0.217	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EEF1E1-BLOC1S5 by DUSP23 expression — UCEC

Explore this box plot interactively →