DUSP23

Across TCGA pan-cancer cohorts, DUSP23 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DUSP23’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DUSP23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DUSP23 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KIRC, KIRP, and BLCA are the cancer types where DUSP23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUSP23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.228	<.001	11	view →
KIRP	Male	III,IV	+1.247	<.001	9	view →
BLCA	All	III,IV	+1.199	<.001	9	view →
KICH	Female	II,III,IV	−1.565	<.001	8	view →
THCA	All	II,III,IV	+0.802	<.001	8	view →
COAD	All	All	+0.606	<.001	8	view →
LIHC	Male	All	+1.604	<.001	7	view →
LUAD	Female	II,III,IV	+0.907	<.001	7	view →
BRCA	All	III,IV	+0.666	<.001	6	view →
STAD	Female	All	+0.904	.004	4	view →
CHOL	All	All	+1.348	<.001	3	view →
LUSC	All	All	+0.348	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DUSP23–KIRC

Open the KIRC breakdown →