DUSP22

Across TCGA pan-cancer cohorts, DUSP22 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DUSP22’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DUSP22 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DUSP22 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where DUSP22 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUSP22 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.485	<.001	9	view →
HNSC	Male	IV	−0.839	<.001	8	view →
LSCC	Male	II,III,IV	−0.764	<.001	8	view →
COAD	Male	II,III,IV	−0.688	<.001	5	view →
CCRCC	All	All	+0.153	.019	3	view →
PDAC	Female	All	+0.332	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DUSP22–LUAD

Open the LUAD breakdown →