DUSP22

Across TCGA patient cohorts, DUSP22 mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP22-associated genes across cancer lineages are CR2, ZNRF1, and SLC25A51P1. Each is linked with DUSP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP22-to-partner and partner-to-DUSP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CR2 grouped by DUSP22-low versus DUSP22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP22→partner) and Y-score (partner→DUSP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CR2 →	-0.629	-2.415	.009	.003	3	2
UCEC	ZNRF1 →	+0.446	+2.716	.001	.003	3	2
UCEC	SLC25A51P1 →	+0.083	+1.961	.001	.009	3	2
LUSC	RNU6-13P →	+0.371	+3.715	.002	.008	3	2
LUSC	RNU7-54P →	+0.449	+4.393	<.001	.008	3	2
LUSC	MIR8075 →	+0.410	+4.606	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

CR2 by DUSP22 expression — UCEC

Explore this box plot interactively →