DUSP22

Across TCGA cell cohorts, DUSP22 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,602 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DUSP22-associated GO terms across cancer lineages are Regulation of macroautophagy, Process utilizing autophagic mechanism, and Autophagy. Each is linked with DUSP22 in more than 11 cancer types. Because this analysis shows association rather than direction, both DUSP22-to-partner and partner-to-DUSP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by DUSP22-low versus DUSP22-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP22→partner) and Y-score (partner→DUSP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of macroautophagy →	+0.080	+0.950	<.001	.001	3	12
LUNG_NSCLC_LUSC	Process utilizing autophagic mechanism →	+0.079	+1.205	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Autophagy →	+0.079	+1.205	<.001	<.001	3	11
LUNG_SCLC	Negative regulation of focal adhesion assembly →	+0.166	+1.435	<.001	<.001	3	11
SKIN	Positive regulation of macroautophagy →	+0.064	+0.687	<.001	<.001	3	10
OESOPHAGUS	Protein polyubiquitination →	+0.052	+0.928	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,602 associations by consensus.

Regulation of macroautophagy by DUSP22 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →