DUSP18

Across TCGA patient cohorts, DUSP18 mutation is significantly associated with the RNA expression of many other genes, with 238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP18-associated genes across cancer lineages are ABCF2P2, RNU6-340P, and RNU6-764P. Each is linked with DUSP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP18-to-partner and partner-to-DUSP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCF2P2 grouped by DUSP18-low versus DUSP18-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP18→partner) and Y-score (partner→DUSP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ABCF2P2 →	+0.193	+4.748	.007	.003	3	2
COAD	RNU6-340P →	+0.363	+7.741	<.001	.009	3	1
COAD	RNU6-764P →	+0.382	+7.741	<.001	.009	3	1
COAD	MIR3171 →	+0.793	+7.741	<.001	.009	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 238 associations by consensus.

ABCF2P2 by DUSP18 expression — HNSC

Explore this box plot interactively →