DUSP18

Across TCGA pan-cancer cohorts, DUSP18 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DUSP18’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DUSP18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DUSP18 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, STAD, and LIHC are the cancer types where DUSP18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUSP18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.895	<.001	10	view →
STAD	All	II,III,IV	+0.765	<.001	8	view →
LIHC	Male	All	+0.522	<.001	8	view →
THCA	Male	All	−0.377	<.001	8	view →
KICH	Female	All	−0.887	<.001	7	view →
HNSC	All	All	+0.465	<.001	6	view →
LUAD	All	All	−0.446	<.001	6	view →
CHOL	Male	All	+2.008	<.001	5	view →
LUSC	Male	All	−0.428	<.001	4	view →
BLCA	All	All	+0.448	.007	3	view →
KIRP	All	All	+0.360	.012	3	view →
KIRC	All	All	+0.236	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DUSP18–COAD

Open the COAD breakdown →