DUSP18

Across TCGA cell cohorts, DUSP18 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUSP18-associated genes across cancer lineages are CHRNA4, ADAD1, and OR4N2. Each is linked with DUSP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP18-to-partner and partner-to-DUSP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNA4 grouped by DUSP18-low versus DUSP18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP18→partner) and Y-score (partner→DUSP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHRNA4 →	+0.018	+4.234	.004	.003	3	1
BLOOD_Leukemia	ADAD1 →	+0.107	+3.551	<.001	.009	3	1
BLOOD_Leukemia	OR4N2 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	SLC36A2 →	+0.011	+3.551	.003	.009	3	1
BLOOD_Leukemia	OPN1MW3 →	+0.061	+4.384	<.001	.006	3	1
LUNG_NSCLC_LUAD	TDRD15 →	+0.378	+3.734	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CHRNA4 by DUSP18 expression — BLOOD_Leukemia

Explore this box plot interactively →