DUSP16

Across TCGA patient cohorts, DUSP16 mutation is significantly associated with the RNA expression of many other genes, with 1,970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP16-associated genes across cancer lineages are RN7SL248P, EOMES, and HSPA4L. Each is linked with DUSP16 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP16-to-partner and partner-to-DUSP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by DUSP16-low versus DUSP16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP16→partner) and Y-score (partner→DUSP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.044	+2.678	<.001	.002	3	2
UCEC	EOMES →	+0.367	+1.857	.001	<.001	3	2
UCEC	HSPA4L →	+0.528	+1.530	.001	.009	3	2
UCEC	BEND7 →	-0.800	-2.321	<.001	<.001	3	2
UCEC	THBS3 →	-0.555	-3.148	<.001	<.001	3	2
PRAD	PHBP14 →	+0.089	+7.939	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,970 associations by consensus.

RN7SL248P by DUSP16 expression — UCEC

Explore this box plot interactively →