DUSP16

Across TCGA cell cohorts, DUSP16 mutation is significantly associated with the RNA expression of many other genes, with 272 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUSP16-associated genes across cancer lineages are MBD3L3, OR5AU1, and MBD3L4. Each is linked with DUSP16 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP16-to-partner and partner-to-DUSP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by DUSP16-low versus DUSP16-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP16→partner) and Y-score (partner→DUSP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MBD3L3 →	+0.020	+4.906	<.001	.006	3	2
SKIN	OR5AU1 →	+0.022	+3.510	.005	.003	3	2
OESOPHAGUS	MBD3L4 →	+0.020	+4.906	<.001	.006	3	1
CNS	PRAMEF12 →	+0.519	+4.315	<.001	.006	3	1
CNS	FSHB →	+0.024	+4.321	<.001	.009	3	1
CNS	TRIM48 →	+0.235	+4.472	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 272 associations by consensus.

MBD3L3 by DUSP16 expression — OESOPHAGUS

Explore this box plot interactively →