DUSP12

Across TCGA patient cohorts, DUSP12 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP12-associated genes across cancer lineages are RNU6-546P, MIR7-2, and MIR4686. Each is linked with DUSP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP12-to-partner and partner-to-DUSP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-546P grouped by DUSP12-low versus DUSP12-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP12→partner) and Y-score (partner→DUSP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-546P →	+0.373	+7.930	<.001	.008	3	2
UCEC	MIR7-2 →	+0.301	+3.399	<.001	.005	3	2
SKCM	MIR4686 →	+0.297	+4.743	<.001	.005	3	1
LUAD	RNU6-747P →	+0.383	+7.930	<.001	.008	3	1
LUAD	RNU7-197P →	+0.558	+7.930	<.001	.008	3	1
UCEC	SAMD11P1 →	+0.297	+2.699	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

RNU6-546P by DUSP12 expression — LUAD

Explore this box plot interactively →