DUSP12

Across TCGA pan-cancer cohorts, DUSP12 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DUSP12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DUSP12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DUSP12 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where DUSP12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUSP12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.120	<.001	12	view →
BLCA	Male	All	+1.093	<.001	11	view →
COAD	Female	All	+0.919	<.001	11	view →
KIRC	Male	IV	+0.734	<.001	11	view →
LIHC	Male	II,III,IV	+1.475	<.001	9	view →
LUAD	Male	All	+0.662	<.001	9	view →
KICH	Female	All	−1.296	<.001	7	view →
STAD	Male	II,III,IV	+0.824	<.001	6	view →
BRCA	All	III,IV	+0.549	<.001	6	view →
THCA	All	All	−0.218	.005	6	view →
CHOL	Male	All	+2.875	<.001	5	view →
LUSC	Male	All	+0.593	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DUSP12–HNSC

Open the HNSC breakdown →