DUSP10

Across TCGA cell cohorts, DUSP10 mutation is significantly associated with the mutation status of many other genes, with 3,453 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUSP10-associated genes across cancer lineages are PTPRG, UPF1, and CD5L. Each is linked with DUSP10 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUSP10-to-partner and partner-to-DUSP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPRG grouped by DUSP10-low versus DUSP10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP10→partner) and Y-score (partner→DUSP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTPRG →	+2.159	+3.807	.007	.007	1	4
LARGE_INTESTINE	UPF1 →	+2.043	+3.693	.009	.009	1	4
BLOOD_Leukemia	CD5L →	+6.321	+6.321	.001	.001	1	3
SKIN	SETDB1 →	+5.053	+4.239	.007	.007	1	3
SKIN	ANKMY1 →	+3.245	+4.807	<.001	<.001	1	3
LARGE_INTESTINE	PPIP5K2 →	+2.043	+3.693	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,453 associations by consensus.

PTPRG by DUSP10 expression — LARGE_INTESTINE

Explore this box plot interactively →