DUS2

Across TCGA patient cohorts, DUS2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUS2-associated genes across cancer lineages are MEK1, eEF2, and EGFR_pY1068. Each is linked with DUS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUS2-to-partner and partner-to-DUS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DUS2-low versus DUS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUS2→partner) and Y-score (partner→DUS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.476	+3.169	.007	.018	3	2
UCEC	eEF2 →	+0.409	+3.169	.018	.019	3	1
UCEC	EGFR_pY1068 →	-0.336	-3.169	.005	.018	3	1
UCEC	ERK2 →	+0.272	+2.459	.003	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.140	-3.160	.020	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.780	+3.584	.001	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MEK1 by DUS2 expression — UCEC

Explore this box plot interactively →