DUOXA2

Across TCGA patient cohorts, DUOXA2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUOXA2-associated genes across cancer lineages are ERK2, Fibronectin, and JNK_pT183_Y185. Each is linked with DUOXA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUOXA2-to-partner and partner-to-DUOXA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DUOXA2-low versus DUOXA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOXA2→partner) and Y-score (partner→DUOXA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.243	+3.584	.009	.002	3	1
UCEC	Fibronectin →	-0.360	-2.986	.024	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.245	-3.169	.002	.019	3	1
UCEC	Lck →	+0.214	+2.459	.027	.020	3	1
UCEC	mTOR_pS2448 →	-0.169	-2.980	.019	.036	3	1
UCEC	Rab25 →	-0.324	-2.459	.043	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ERK2 by DUOXA2 expression — UCEC

Explore this box plot interactively →