DUOXA2

Across TCGA pan-cancer cohorts, DUOXA2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DUOXA2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DUOXA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DUOXA2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where DUOXA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUOXA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+1.757	<.001	9	view →
KIRC	All	All	−0.107	<.001	9	view →
THCA	All	All	−0.713	.004	7	view →
LIHC	All	II,III,IV	+0.838	.005	6	view →
KIRP	Male	II,III,IV	−0.080	<.001	5	view →
BRCA	All	III,IV	−0.197	<.001	4	view →
STAD	Male	IV	−5.194	.029	2	view →
READ	Female	All	+3.199	.005	2	view →
BLCA	Female	All	−2.525	.040	2	view →
HNSC	Female	III,IV	−1.974	.032	2	view →
PRAD	All	All	−0.695	.001	2	view →
LUAD	All	III,IV	−0.373	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DUOXA2–COAD

Open the COAD breakdown →