DUOXA2

Across TCGA cell cohorts, DUOXA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,650 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible DUOXA2-associated GO terms across cancer lineages are Regulation of response to endoplasmic reticulum stress, Skin development, and Response to steroid hormone. Each is linked with DUOXA2 in more than 8 cancer types. Because this analysis shows association rather than direction, both DUOXA2-to-partner and partner-to-DUOXA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of response to endoplasmic reticulum stress grouped by DUOXA2-low versus DUOXA2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOXA2→partner) and Y-score (partner→DUOXA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of response to endoplasmic reticulum stress →	+0.063	+0.486	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Skin development →	+0.124	+0.660	<.001	.008	3	9
UPPER_AERODIGESTIVE_TRACT	Response to steroid hormone →	+0.091	+0.607	<.001	.003	3	9
STOMACH	Cellular response to steroid hormone stimulus →	+0.075	+0.217	.003	.007	3	9
BONE	Positive regulation of hydrogen peroxide biosynthetic process →	-0.170	-0.310	<.001	.001	3	9
OESOPHAGUS	Regulation of intrinsic apoptotic signaling pathway →	+0.056	+0.546	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,650 associations by consensus.

Regulation of response to endoplasmic reticulum stress by DUOXA2 expression — PANCREAS

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