DUOXA1

Across TCGA pan-cancer cohorts, DUOXA1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DUOXA1 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DUOXA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DUOXA1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where DUOXA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.988	0.827	.023	10	view →
LUAD	DFS	Tertile	II,III,IV	0.732	0.993	.009	4	view →
HNSC	OS	Median	All	0.811	0.644	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DUOXA1–LSCC (DFS)

Open the LSCC breakdown →