DUOXA1

Across TCGA pan-cancer cohorts, DUOXA1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DUOXA1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DUOXA1 RNA is repressed in tumor relative to normal tissue. In most cancer types DUOXA1 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

LUAD, KIRC, and LUSC are the cancer types where DUOXA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUOXA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.858	<.001	11	view →
KIRC	Male	II,III,IV	−0.353	<.001	11	view →
LUSC	Male	II,III,IV	−2.121	<.001	6	view →
KICH	Male	All	−0.540	<.001	5	view →
COAD	All	III,IV	+0.320	.018	4	view →
PAAD	All	All	+1.817	.034	2	view →
PRAD	All	All	−1.772	<.001	2	view →
STAD	All	IV	−1.609	<.001	2	view →
CHOL	All	All	+1.544	.001	2	view →
ESCA	Male	All	−2.110	.030	1	view →
HNSC	Female	All	−0.660	.033	1	view →
THCA	Male	III,IV	−0.644	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DUOXA1–LUAD

Open the LUAD breakdown →