DUOXA1

Across TCGA patient cohorts, DUOXA1 mutation is significantly associated with the RNA expression of many other genes, with 506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUOXA1-associated genes across cancer lineages are KRTAP19-8, KRTAP8-3P, and LINC02796. Each is linked with DUOXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUOXA1-to-partner and partner-to-DUOXA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-8 grouped by DUOXA1-low versus DUOXA1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOXA1→partner) and Y-score (partner→DUOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	KRTAP19-8 →	+0.307	+5.758	<.001	.003	3	2
LIHC	KRTAP8-3P →	+0.260	+5.544	<.001	.004	3	2
BRCA	LINC02796 →	+0.266	+6.382	<.001	.001	3	2
COAD	RNU6-633P →	+0.432	+3.789	<.001	.004	3	2
COAD	SELENOOLP →	+0.713	+3.266	.002	.009	3	2
UCEC	GAS2L1 →	+0.703	+3.212	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 506 associations by consensus.

KRTAP19-8 by DUOXA1 expression — LIHC

Explore this box plot interactively →