DUOXA1

Across TCGA patient cohorts, DUOXA1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUOXA1-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and MEK1. Each is linked with DUOXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUOXA1-to-partner and partner-to-DUOXA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DUOXA1-low versus DUOXA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOXA1→partner) and Y-score (partner→DUOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.541	+3.169	.005	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.283	-3.169	.002	.019	3	1
UCEC	MEK1 →	+0.422	+3.169	.035	.020	3	1
UCEC	PEA-15_pS116 →	+0.473	+3.169	.013	.020	3	1
UCEC	TIGAR →	+0.165	+3.196	.048	.010	3	1
UCEC	EGFR_pY1068 →	-0.301	-3.169	.029	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

eEF2 by DUOXA1 expression — UCEC

Explore this box plot interactively →