DUOXA1

Across TCGA cell cohorts, DUOXA1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUOXA1-associated genes across cancer lineages are TAS2R7, SERPINB12, and MS4A10. Each is linked with DUOXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUOXA1-to-partner and partner-to-DUOXA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R7 grouped by DUOXA1-low versus DUOXA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOXA1→partner) and Y-score (partner→DUOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAS2R7 →	+0.014	+4.437	<.001	.004	3	1
LARGE_INTESTINE	SERPINB12 →	+0.128	+3.823	<.001	.006	3	1
LARGE_INTESTINE	MS4A10 →	+0.010	+3.684	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TAS2R7 by DUOXA1 expression — LARGE_INTESTINE

Explore this box plot interactively →