DUOX2

Across TCGA cell cohorts, DUOX2 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DUOX2-associated genes across cancer lineages are ABCC12, VN1R2, and SLC32A1. Each is linked with DUOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUOX2-to-partner and partner-to-DUOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCC12 grouped by DUOX2-low versus DUOX2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX2→partner) and Y-score (partner→DUOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ABCC12 →	+0.054	+2.966	<.001	.005	3	2
LUNG_NSCLC_LUAD	VN1R2 →	+0.031	+2.959	<.001	.004	3	2
URINARY_TRACT	SLC32A1 →	+0.012	+4.087	<.001	.009	3	1
URINARY_TRACT	ACOD1 →	+0.040	+4.217	<.001	.005	3	1
URINARY_TRACT	OR52N4 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	KRTAP1-4 →	+0.072	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

ABCC12 by DUOX2 expression — BLOOD_Leukemia

Explore this box plot interactively →