DPPA2 upstream binding RNAGenealiases: DUM · LINC00883 · LINC0883
Q-omics provides the consensus-scored DUBR profile across patient tissues and cancer cell-line models. DUBR expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, DUBR is differentially expressed in 16, with the highest sampling consensus in HNSC. Additionally, DUBR RNA expression shows 19,723 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, HNSC, and ACC as cancer lineages where DUBR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DUBR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DUBR survival associations across molecular data types. DUBR RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DUBR RNA expression–survival associations across cancer types. High DUBR expression shows unfavorable associations in COAD, CESC, LAML and ACC, but favorable associations in KIRC and BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for DUBR RNA expression.
This table summarizes DUBR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for DUBR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DUBR shows lower tumor expression in THCA, LUAD, KICH, UCEC and KIRC and higher tumor expression in HNSC. The HNSC box plot shows higher DUBR RNA expression in tumor versus normal tissue (log2 FC = +0.746, t-test p < 0.001).
This table shows molecular features associated with DUBR in patient tissues and cancer cell lines. In patient samples, DUBR shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
