DTX4

Across TCGA patient cohorts, DTX4 mutation is significantly associated with the RNA expression of many other genes, with 3,870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX4-associated genes across cancer lineages are RNA5SP413, CTAG1B, and SNORD114-10. Each is linked with DTX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DTX4-to-partner and partner-to-DTX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by DTX4-low versus DTX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX4→partner) and Y-score (partner→DTX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+0.797	+1.914	<.001	<.001	3	3
HNSC	CTAG1B →	+0.073	+6.111	<.001	.002	3	2
HNSC	SNORD114-10 →	+0.887	+5.303	<.001	.006	3	2
HNSC	SNORD31B →	+0.572	+7.357	<.001	<.001	3	2
CESC	RN7SKP258 →	+0.093	+4.144	<.001	.009	3	2
BRCA	ATP6V1G1P3 →	+0.306	+4.030	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,870 associations by consensus.

RNA5SP413 by DTX4 expression — UCEC

Explore this box plot interactively →