DTX4

Across TCGA pan-cancer cohorts, DTX4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated DTX4 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher DTX4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DTX4 expression acts as an unfavorable survival marker, although some lineages such as THCA and LGG show a favorable association.

THCA, UVM, and LGG are the cancer types where DTX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	1.000	0.858	<.001	53	view →
UVM	DFS	Median	All	0.437	0.720	.001	42	view →
LGG	DFS	Tertile	All	0.886	0.757	<.001	29	view →
LUSC	DFS	Quartile	All	0.283	0.517	.005	20	view →
CESC	DFS	Quartile	All	0.606	0.812	.004	20	view →
BLCA	OS	Quartile	All	0.592	0.409	.007	16	view →
READ	DFS	Quartile	IV	0.246	0.794	<.001	12	view →
SKCM	OS	Quartile	All	0.242	0.439	<.001	12	view →
THYM	DFS	Median	All	0.951	0.784	.001	10	view →
COAD	DFS	Quartile	III,IV	0.481	0.761	.018	9	view →
MESO	DFS	Median	III,IV	0.291	0.452	.026	9	view →
DLBC	DFS	Median	All	0.584	1.000	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

DTX4–THCA (OS)

Open the THCA breakdown →