DTX4

Across TCGA patient cohorts, DTX4 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX4-associated genes across cancer lineages are FoxM1, mTOR_pS2448, and ATM. Each is linked with DTX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTX4-to-partner and partner-to-DTX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by DTX4-low versus DTX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX4→partner) and Y-score (partner→DTX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.186	+1.584	.031	.009	3	2
UCEC	mTOR_pS2448 →	-0.104	-2.067	.036	.005	3	2
UCEC	ATM →	-0.406	-1.584	.007	.009	3	2
UCEC	A-Raf_pS299 →	-0.103	-2.087	.009	.005	3	1
UCEC	ERK2 →	+0.184	+1.584	.004	.009	3	1
UCEC	JNK2 →	+0.192	+1.727	.003	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FoxM1 by DTX4 expression — UCEC

Explore this box plot interactively →