DTX4

Across TCGA cell cohorts, DTX4 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DTX4-associated genes across cancer lineages are ACOT6, GYPB, and OXT. Each is linked with DTX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTX4-to-partner and partner-to-DTX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACOT6 grouped by DTX4-low versus DTX4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX4→partner) and Y-score (partner→DTX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ACOT6 →	+0.060	+3.562	.005	.007	3	2
SKIN	GYPB →	+0.099	+4.467	.009	.004	3	1
CNS	OXT →	+0.046	+3.700	<.001	.003	3	1
CNS	H2AP →	+0.156	+4.000	<.001	.002	3	1
CNS	OR10J1 →	+0.003	+4.357	<.001	.004	3	1
CNS	CCL16 →	+0.018	+4.357	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ACOT6 by DTX4 expression — CNS

Explore this box plot interactively →