DTX2P1-UPK3BP1-PMS2P11

Across TCGA pan-cancer cohorts, DTX2P1-UPK3BP1-PMS2P11 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DTX2P1-UPK3BP1-PMS2P11 data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DTX2P1-UPK3BP1-PMS2P11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DTX2P1-UPK3BP1-PMS2P11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRC, HNSC, and ACC are the cancer types where DTX2P1-UPK3BP1-PMS2P11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.555	0.723	<.001	121	view →
HNSC	DFS	Quartile	All	0.836	0.687	<.001	83	view →
ACC	DFS	Quartile	All	0.252	0.742	<.001	77	view →
LGG	DFS	Median	All	0.625	0.838	<.001	54	view →
KICH	OS	Tertile	All	0.715	1.000	.004	41	view →
THCA	DFS	Quartile	II,III,IV	0.559	0.974	.006	16	view →
SKCM	OS	Median	III,IV	0.488	0.255	.004	15	view →
UVM	DFS	Quartile	III,IV	0.275	0.806	.013	15	view →
PAAD	DFS	Quartile	All	0.291	0.564	.011	15	view →
READ	OS	Median	II,III,IV	0.826	0.337	.016	14	view →
LUSC	OS	Quartile	All	0.835	0.702	.025	13	view →
OV	DFS	Median	III,IV	0.493	0.566	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DTX2P1-UPK3BP1-PMS2P11–KIRC (DFS)

Open the KIRC breakdown →