DTX2

Across TCGA pan-cancer cohorts, DTX2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DTX2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DTX2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DTX2 is over-expressed in tumor.

LUAD, CCRCC, and LSCC are the cancer types where DTX2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DTX2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.819	<.001	9	view →
CCRCC	All	III,IV	+0.594	<.001	8	view →
LSCC	Male	III,IV	+0.588	<.001	8	view →
PDAC	All	All	+0.364	.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DTX2–LUAD

Open the LUAD breakdown →