DTWD2

Across TCGA pan-cancer cohorts, DTWD2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DTWD2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DTWD2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DTWD2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where DTWD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.733	0.506	.009	30	view →
UCEC	DFS	Median	II,III,IV	0.944	0.482	.004	26	view →
LUAD	DFS	Median	II,III,IV	0.449	0.744	.010	15	view →
PDAC	OS	Tertile	II,III,IV	0.585	0.408	.020	10	view →
LSCC	DFS	Tertile	II,III,IV	0.562	0.833	.021	8	view →
GBM	OS	Tertile	All	0.733	0.886	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DTWD2–HNSC (DFS)

Open the HNSC breakdown →