DTWD2

Across TCGA pan-cancer cohorts, DTWD2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DTWD2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DTWD2 RNA is repressed in tumor relative to normal tissue. In most cancer types DTWD2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where DTWD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DTWD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.238	<.001	9	view →
KICH	All	II,III,IV	−1.164	<.001	8	view →
KIRC	Male	All	−0.416	<.001	8	view →
BRCA	All	III,IV	+0.395	.013	5	view →
COAD	All	All	−0.375	.002	5	view →
LUSC	Male	III,IV	−0.410	.016	3	view →
KIRP	Male	All	−0.537	.003	2	view →
LIHC	All	All	+0.381	.001	2	view →
CHOL	All	All	+0.530	.027	1	view →
READ	All	All	−0.413	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DTWD2–THCA

Open the THCA breakdown →