DTWD2

Across TCGA patient cohorts, DTWD2 mutation is significantly associated with the RNA expression of many other genes, with 1,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTWD2-associated genes across cancer lineages are MIR208A, TUBAP4, and MIR8078. Each is linked with DTWD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTWD2-to-partner and partner-to-DTWD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR208A grouped by DTWD2-low versus DTWD2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTWD2→partner) and Y-score (partner→DTWD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR208A →	+0.368	+8.471	<.001	.005	3	2
UCEC	TUBAP4 →	+0.169	+2.133	<.001	.004	3	2
SKCM	MIR8078 →	+0.754	+3.854	<.001	.004	3	1
UCEC	TAF15 →	+0.439	+3.491	.009	.002	3	1
UCEC	MMP28 →	-0.484	-3.989	.004	<.001	3	1
UCEC	KRT8P49 →	+0.307	+2.906	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,830 associations by consensus.

MIR208A by DTWD2 expression — BRCA

Explore this box plot interactively →