DTWD2

Across TCGA patient cohorts, DTWD2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTWD2-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with DTWD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTWD2-to-partner and partner-to-DTWD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DTWD2-low versus DTWD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTWD2→partner) and Y-score (partner→DTWD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.472	+2.700	.003	.006	3	1
UCEC	EGFR_pY1068 →	-0.339	-3.169	.002	.019	3	1
UCEC	eIF4E →	+0.220	+2.700	.020	.006	3	1
UCEC	ERK2 →	+0.300	+2.700	<.001	.006	3	1
UCEC	GAPDH →	+0.657	+3.169	.006	.018	3	1
UCEC	GATA6 →	-0.216	-3.307	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by DTWD2 expression — UCEC

Explore this box plot interactively →