DTWD2

Across TCGA cell cohorts, DTWD2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DTWD2-associated genes across cancer lineages are LHCGR, ELOA3DP, and OR13G1. Each is linked with DTWD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTWD2-to-partner and partner-to-DTWD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LHCGR grouped by DTWD2-low versus DTWD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTWD2→partner) and Y-score (partner→DTWD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LHCGR →	+0.050	+4.467	<.001	.004	3	1
LARGE_INTESTINE	ELOA3DP →	+0.039	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

LHCGR by DTWD2 expression — LARGE_INTESTINE

Explore this box plot interactively →