DTWD1

Across TCGA patient cohorts, DTWD1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTWD1-associated genes across cancer lineages are Notch1, p62 Lck ligand, and STAT3_pY705. Each is linked with DTWD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTWD1-to-partner and partner-to-DTWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DTWD1-low versus DTWD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTWD1→partner) and Y-score (partner→DTWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.177	+2.584	.006	.011	3	1
UCEC	p62 Lck ligand →	+0.481	+3.009	.001	.019	2	2
UCEC	STAT3_pY705 →	-0.529	-3.449	<.001	.005	3	1
UCEC	VHL →	-1.051	-2.321	<.001	.034	3	1
UCEC	Caspase-8 →	-0.238	-3.295	.042	.009	3	1
UCEC	Cyclin-B1 →	+0.719	+3.169	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Notch1 by DTWD1 expression — UCEC

Explore this box plot interactively →