DTWD1

Across TCGA pan-cancer cohorts, DTWD1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DTWD1 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher DTWD1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DTWD1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

SCLC, UCEC, and KIRC are the cancer types where DTWD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	All	0.437	0.753	.001	74	view →
UCEC	OS	Median	II,III,IV	0.784	0.396	<.001	70	view →
KIRC	OS	Quartile	All	0.874	0.749	<.001	58	view →
UVM	OS	Median	All	0.875	0.506	<.001	57	view →
KIRP	DFS	Median	IV	0.039	0.623	.001	45	view →
UCS	DFS	Quartile	III,IV	0.567	0.179	.003	36	view →
KICH	DFS	Tertile	III,IV	0.257	0.931	.002	29	view →
CESC	OS	Quartile	III,IV	0.566	0.911	.016	20	view →
SARC	OS	Median	All	0.611	0.335	<.001	19	view →
THYM	DFS	Median	II,III,IV	0.880	0.560	.003	15	view →
ACC	DFS	Quartile	III,IV	0.923	0.537	.024	15	view →
BRCA	DFS	Median	III,IV	0.921	0.831	.019	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DTWD1–SCLC (OS)

Open the SCLC breakdown →