DTNB

Across TCGA pan-cancer cohorts, DTNB Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DTNB data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DTNB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DTNB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and KICH are the cancer types where DTNB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.181	0.661	.005	48	view →
UCEC	DFS	Median	II,III,IV	0.928	0.432	.014	16	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ESCA	OS	Median	All	0.080	0.701	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DTNB–HNSC (OS)

Open the HNSC breakdown →