DTNB

Across TCGA pan-cancer cohorts, DTNB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DTNB data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DTNB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DTNB expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where DTNB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.842	0.370	.011	22	view →
UCEC	DFS	Median	All	0.924	0.770	.009	12	view →
CCRCC	OS	Tertile	III,IV	0.985	0.104	.024	8	view →
LSCC	DFS	Median	All	0.728	0.848	.029	3	view →
GBM	DFS	Quartile	All	0.826	0.569	.039	1	view →
PDAC	OS	Quartile	All	0.923	0.872	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DTNB–LUAD (OS)

Open the LUAD breakdown →