DTNB

Across TCGA patient cohorts, DTNB protein abundance is significantly associated with the RNA expression of many other genes, with 9,248 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DTNB-associated genes across cancer lineages are HLF, ENPP5, and NR3C2. Each is linked with DTNB in more than 4 cancer types. Because this analysis shows association rather than direction, both DTNB-to-partner and partner-to-DTNB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DTNB versus HLF in GBM, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNB→partner) and Y-score (partner→DTNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HLF →	+1.036	+0.242	<.001	.005	3	5
GBM	ENPP5 →	+1.493	+0.213	<.001	.002	3	5
GBM	NR3C2 →	+0.873	+0.237	<.001	.004	3	5
UCEC	ELAPOR1 →	+1.577	+0.230	<.001	<.001	3	5
HNSC	AMOT →	+1.306	+0.413	<.001	<.001	3	5
GBM	REPS2 →	+1.274	+0.338	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,248 associations by consensus.

DTNB vs HLF — GBM

Explore this scatter interactively →