DTNB

Across TCGA patient cohorts, DTNB mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTNB-associated genes across cancer lineages are eIF4E, JNK2, and mTOR_pS2448. Each is linked with DTNB in more than 1 cancer types. Because this analysis shows association rather than direction, both DTNB-to-partner and partner-to-DTNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DTNB-low versus DTNB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNB→partner) and Y-score (partner→DTNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+3.335	.017	.005	3	2
UCEC	JNK2 →	+0.191	+1.817	.006	.015	3	2
UCEC	mTOR_pS2448 →	-0.129	-2.202	.014	.010	3	2
UCEC	ATM →	-0.367	-1.362	.022	.037	3	2
UCEC	Caspase-7-cleavedD198 →	+0.508	+1.662	.015	.011	3	2
UCEC	4E-BP1 →	+0.283	+2.000	.003	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by DTNB expression — UCEC

Explore this box plot interactively →