DTNA

Across TCGA patient cohorts, DTNA protein abundance is significantly associated with the RNA expression of many other genes, with 8,780 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DTNA-associated genes across cancer lineages are ADH1B, C7, and SSPN. Each is linked with DTNA in more than 6 cancer types. Because this analysis shows association rather than direction, both DTNA-to-partner and partner-to-DTNA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DTNA versus ADH1B in COAD, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNA→partner) and Y-score (partner→DTNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADH1B →	+1.769	+0.767	<.001	<.001	3	7
LSCC	C7 →	+1.805	+0.429	<.001	<.001	3	6
UCEC	SSPN →	+0.838	+0.591	<.001	<.001	3	6
UCEC	MFAP4 →	+1.790	+0.687	<.001	<.001	3	6
PDAC	ASPA →	+0.490	+0.399	.001	.009	3	6
LUAD	ADAMTS8 →	+0.763	+0.353	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,780 associations by consensus.

DTNA vs ADH1B — COAD

Explore this scatter interactively →