DTNA

Across TCGA pan-cancer cohorts, DTNA RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DTNA data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DTNA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DTNA expression acts as an unfavorable survival marker, although some lineages such as KIRP and PAAD show a favorable association.

BLCA, KIRP, and UCEC are the cancer types where DTNA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.292	0.585	<.001	120	view →
KIRP	OS	Tertile	II,III,IV	0.960	0.640	<.001	77	view →
UCEC	OS	Tertile	All	0.562	0.753	<.001	64	view →
PAAD	OS	Median	All	0.492	0.265	<.001	64	view →
LGG	OS	Median	All	0.751	0.868	<.001	44	view →
KIRC	OS	Median	II,III,IV	0.767	0.621	.001	32	view →
ACC	DFS	Median	II,III,IV	0.690	0.295	.004	30	view →
ESCA	OS	Median	All	0.645	0.466	.009	30	view →
COAD	DFS	Tertile	All	0.720	0.813	.005	24	view →
MESO	DFS	Median	IV	0.189	0.521	.002	15	view →
HNSC	OS	Tertile	All	0.600	0.711	.029	10	view →
READ	DFS	Median	All	0.445	0.667	.015	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DTNA–BLCA (OS)

Open the BLCA breakdown →