DTNA

Across TCGA patient cohorts, DTNA mutation is significantly associated with the RNA expression of many other genes, with 4,692 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTNA-associated genes across cancer lineages are SKA1, TK1, and E2F2. Each is linked with DTNA in more than 3 cancer types. Because this analysis shows association rather than direction, both DTNA-to-partner and partner-to-DTNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by DTNA-low versus DTNA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNA→partner) and Y-score (partner→DTNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.653	+1.788	<.001	<.001	3	4
UCEC	TK1 →	+0.459	+1.669	<.001	<.001	3	4
UCEC	E2F2 →	+0.542	+1.415	<.001	<.001	3	4
UCEC	BLVRB →	+0.403	+1.658	.001	<.001	3	4
UCEC	CDC45 →	+0.675	+1.701	<.001	<.001	3	4
SKCM	PKMYT1 →	+0.718	+2.835	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,692 associations by consensus.

SKA1 by DTNA expression — UCEC

Explore this box plot interactively →