DTNA

Across TCGA patient cohorts, DTNA mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTNA-associated genes across cancer lineages are PCNA, 14-3-3_beta, and eEF2. Each is linked with DTNA in more than 2 cancer types. Because this analysis shows association rather than direction, both DTNA-to-partner and partner-to-DTNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DTNA-low versus DTNA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNA→partner) and Y-score (partner→DTNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.241	+2.000	.005	.031	3	3
UCEC	14-3-3_beta →	-0.071	-1.447	.004	.004	3	2
UCEC	eEF2 →	+0.228	+1.459	.010	.009	3	2
UCEC	eIF4E →	+0.146	+1.121	.005	.005	3	2
UCEC	FoxM1 →	+0.147	+1.000	.022	.012	3	2
UCEC	GAPDH →	+0.361	+1.000	.007	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

PCNA by DTNA expression — SKCM

Explore this box plot interactively →