DTNA

Across TCGA cell cohorts, DTNA mutation is significantly associated with the RNA expression of many other genes, with 260 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DTNA-associated genes across cancer lineages are TBL1Y, SIRPD, and CD300H. Each is linked with DTNA in more than 1 cancer types. Because this analysis shows association rather than direction, both DTNA-to-partner and partner-to-DTNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by DTNA-low versus DTNA-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNA→partner) and Y-score (partner→DTNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	2
STOMACH	SIRPD →	+0.181	+4.129	<.001	.007	3	2
LARGE_INTESTINE	CD300H →	+0.020	+3.000	<.001	.003	3	2
STOMACH	OR4N2 →	+0.033	+4.794	.001	.001	3	2
BLOOD_Leukemia	KLF18 →	+0.006	+5.201	.003	.006	3	2
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 260 associations by consensus.

TBL1Y by DTNA expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →