DTL

Across TCGA pan-cancer cohorts, DTL mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DTL data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DTL mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DTL expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

HNSC, UCEC, and GBM are the cancer types where DTL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.848	1.000	.002	37	view →
UCEC	DFS	Median	All	1.000	0.902	.042	6	view →
GBM	DFS	Quartile	All	0.523	0.214	.045	2	view →
LUAD	DFS	Median	All	0.492	0.873	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DTL–HNSC (OS)

Open the HNSC breakdown →